A comparison of the pharmacology of two potent analgesic agents, piminodine (Win 14,098-2) and Win 13,797, with morphine and meperidine.

When meperidine (Demerol) was shown to possess marked analgesic properties (Eisleb and Schaumann, 1939) and thus became the first potent synthetic analgesic drug, the importance of the 1,4-substituted piperidine nucleus in providing analgesic activity became apparent. Many modifications of this basic chemical structure have been synthesized and studied pharmacologically in an attempt to achieve greater analgesic potency. Two such derivatives, synthesized by Elpern e$ uZ. (1959), showing analgesic activity greater than meperidine are piminodine (Win 14,098-2, ethyl 4-phenyl-l[ 3(phenylamino)propyl] piperidine-4-carboxylate) and Win 13,797 (ethyl 4-phenyl-l-[ 2-(phenylamino)ethyl]piperidine-4-carboxylate). Pharmacologic studies of these two derivatives in comparison with meperidine and morphine are presented in this report.